The Topographic Effect of Zinc Oxide Nanoflowers on Osteoblast Growth and Osseointegration

Authors

  • Jung Kyu Park,

    1. Department of Material Science and Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang, Kyungbuk, 790–784 (Korea)
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  • Yong-Jin Kim,

    1. National CRI Center for Semiconductor Nanorods, Department of Physics and Astronomy, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul, 151–742 (Korea)
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  • Junseok Yeom,

    1. Department of Material Science and Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang, Kyungbuk, 790–784 (Korea)
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  • Ju Hyeong Jeon,

    1. Department of Material Science and Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang, Kyungbuk, 790–784 (Korea)
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  • Gyu-Chul Yi,

    1. National CRI Center for Semiconductor Nanorods, Department of Physics and Astronomy, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul, 151–742 (Korea)
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  • Jung Ho Je,

    1. Department of Material Science and Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang, Kyungbuk, 790–784 (Korea)
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  • Sei Kwang Hahn

    Corresponding author
    1. Department of Material Science and Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang, Kyungbuk, 790–784 (Korea)
    • Department of Material Science and Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang, Kyungbuk, 790–784 (Korea).
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Abstract

original image

ZnO nanoflowers prepared by a solution-based hydrothermal growth method result in effective osteoblast growth with higher DNA content, ALP activity, and adhesion strength than those on ZnO film. Furthermore, ZnO nanoflowers are tightly osseointegrated into the regenerated bones. The approach for fabricating nanoflower structures on biomaterial surfaces can be successfully exploited for various bone tissue engineering applications.

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