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Antitags: Nanostructured Tools for Developing SERS-Based ELISA Analogs

Authors

  • Nekane Guarrotxena,

    1. Instituto de Ciencia y Tecnología de Polímeros (ICTP), Consejo Superior de Investigaciones Científicas (CSIC), Juan de la Cierva 3, Madrid 28006 (SPAIN)
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  • Bin Liu,

    1. Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576 (SINGAPORE)
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  • Laura Fabris,

    Corresponding author
    1. Department of Materials Science and Engineering, Institute for Advanced Materials Devices and Nanotechnology Rutgers, The State University of New Jersey, Piscataway, NJ 08854 (USA)
    • Department of Materials Science and Engineering, Institute for Advanced Materials Devices and Nanotechnology Rutgers, The State University of New Jersey, Piscataway, NJ 08854 (USA).
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  • Guillermo C. Bazan

    Corresponding author
    1. Department of Chemistry & Biochemistry and Materials, Center for Polymers and Organic Solids, University of California, Santa Barbara, CA 93106 (USA)
    • Department of Chemistry & Biochemistry and Materials, Center for Polymers and Organic Solids, University of California, Santa Barbara, CA 93106 (USA)
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Abstract

Antitags are reported. These materials bring together two or more metallic nanoparticles by using a dithiolated organic molecule and contain antibodies on the surface to function as antigen-specific recognition elements. The linker position leads to a behavior characteristic of surface enhanced Raman spectroscopy (SERS). In conjunction with a surface containing capture antibody, antitags can be used to detect antigens with sensitivities approaching those of the widely used enzyme linked immunosorbent assay (ELISA).

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