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Keywords:

  • Cancer therapy;
  • Hollow nanospheres;
  • Mesoporous;
  • Preloading;
  • Silica
Thumbnail image of graphical abstract

Hollow mesoporous silica (HMS) spheres preloaded with the anticancer drug Doxorubicin (DOX) can be synthesized by using porous CaCO3 spheres as templates (see figure). With good biocompatibility, the HMS@DOX spheres exhibit a greatly enhanced therapeutic effect towards tumor cells ; this enhancement may be caused by the efficient protection of DOX and the pH-sensitive release of DOX, together with enhanced intracellular delivery.