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Advanced Materials

Templating Synthesis of Preloaded Doxorubicin in Hollow Mesoporous Silica Nanospheres for Biomedical Applications

Authors

  • Yang Zhao,

    1. Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui, 230026 (P. R. China) Fax: +86 551 3603040
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Li-Ning Lin,

    1. Department of Materials of Science and Engineering, University of Science and Technology of China, Hefei, Anhui, 230026 (P. R. China)
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Yang Lu,

    1. Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui, 230026 (P. R. China) Fax: +86 551 3603040
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  • Shao-Feng Chen,

    1. Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui, 230026 (P. R. China) Fax: +86 551 3603040
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  • Liang Dong,

    1. Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui, 230026 (P. R. China) Fax: +86 551 3603040
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  • Shu-Hong Yu

    Corresponding author
    1. Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui, 230026 (P. R. China) Fax: +86 551 3603040
    • Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui, 230026 (P. R. China) Fax: +86 551 3603040.
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Abstract

Hollow mesoporous silica (HMS) spheres preloaded with the anticancer drug Doxorubicin (DOX) can be synthesized by using porous CaCO3 spheres as templates (see figure). With good biocompatibility, the HMS@DOX spheres exhibit a greatly enhanced therapeutic effect towards tumor cells ; this enhancement may be caused by the efficient protection of DOX and the pH-sensitive release of DOX, together with enhanced intracellular delivery.

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