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Collective Cell Migration on Artificial Extracellular Matrix Proteins Containing Full-Length Fibronectin Domains

Authors

  • Eileen Fong,

    1. Department of Bioengineering, California Institute of Technology, Pasadena, California 91125, USA
    Current affiliation:
    1. Present Address: School of Materials Science and Engineering Nanyang Technological University, 50 Nanyang Avenue N4.1-02-14, Singapore 639798
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  • David A. Tirrell

    Corresponding author
    1. Division of Chemistry and Chemical Engineering, Joseph J. Jacobs Institute for Molecular Engineering for Medicine, California Institute of Technology, Pasadena, California 91125, USA
    • Department of Bioengineering, California Institute of Technology, Pasadena, California 91125, USA.
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Abstract

Protein-based biomaterials that promote rapid wound healing are prepared by expression of artificial genes in bacterial cells. Artificial extracellular matrix proteins containing full-length fibronectin domains 9 and 10 exhibit strong α5β1 integrin binding and support rapid spreading, proliferation, and collective migration of fibroblasts.

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