Temperature-Responsive Polymer Brushes Switching from Bactericidal to Cell-Repellent

Authors

  • Xavier Laloyaux,

    1. Institute of Condensed Matter and Nanosciences–Bio & Soft Matter, Université catholique de Louvain, Croix du Sud 1/4, 1348 Louvain-la-Neuve (Belgium)
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  • Emilie Fautré,

    1. Institute of Condensed Matter and Nanosciences–Bio & Soft Matter, Université catholique de Louvain, Croix du Sud 1/4, 1348 Louvain-la-Neuve (Belgium)
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  • Thomas Blin,

    1. Laboratoire Polymères, Biopolymères, Surfaces, Université de Rouen, UMR 6270 & FR 3038, Bd Maurice de Broglie, 76821 Mont Saint Aignan (France)
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  • Viswas Purohit,

    1. Laboratoire Polymères, Biopolymères, Surfaces, Université de Rouen, UMR 6270 & FR 3038, Bd Maurice de Broglie, 76821 Mont Saint Aignan (France)
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  • Jérôme Leprince,

    1. Laboratoire de Différenciation et Communication Neuronale, et Neuroendocrine, Université de Rouen, INSERM U982, Place Emile Blondel, 76821, Mont Saint Aignan (France)
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  • Thierry Jouenne,

    1. Laboratoire Polymères, Biopolymères, Surfaces, Université de Rouen, UMR 6270 & FR 3038, Bd Maurice de Broglie, 76821 Mont Saint Aignan (France)
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  • Alain M. Jonas,

    Corresponding author
    1. Institute of Condensed Matter and Nanosciences–Bio & Soft Matter, Université catholique de Louvain, Croix du Sud 1/4, 1348 Louvain-la-Neuve (Belgium)
    • Institute of Condensed Matter and Nanosciences–Bio & Soft Matter, Université catholique de Louvain, Croix du Sud 1/4, 1348 Louvain-la-Neuve (Belgium).
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  • Karine Glinel

    Corresponding author
    1. Institute of Condensed Matter and Nanosciences–Bio & Soft Matter, Université catholique de Louvain, Croix du Sud 1/4, 1348 Louvain-la-Neuve (Belgium)
    • Institute of Condensed Matter and Nanosciences–Bio & Soft Matter, Université catholique de Louvain, Croix du Sud 1/4, 1348 Louvain-la-Neuve (Belgium).
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Abstract

original image

The composition of temperature-responsive copolymer brushes based on oligo(ethylene glycol) methacrylates is tuned to obtain a collapse temperature of ∼35 °C. The chains are grafted by antibacterial magainin I peptide, whose activity is tested at different temperatures against various bacteria. The brushes switch from bactericidal to cell-repellent below and slightly above 35 °C, respectively, due to the progressive vertical collapse of the brush.

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