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A DNA Nanostructure-based Biomolecular Probe Carrier Platform for Electrochemical Biosensing

Authors

  • Hao Pei,

    1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800 (P. R. China)
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  • Na Lu,

    1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800 (P. R. China)
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  • Yanli Wen,

    1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800 (P. R. China)
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  • Shiping Song,

    1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800 (P. R. China)
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  • Yan Liu,

    1. Department of Chemistry and Biochemistry & The Biodesign Institute, Arizona State University, Tempe, AZ (USA)
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  • Hao Yan,

    Corresponding author
    1. Department of Chemistry and Biochemistry & The Biodesign Institute, Arizona State University, Tempe, AZ (USA)
    • Department of Chemistry and Biochemistry & The Biodesign Institute, Arizona State University, Tempe, AZ (USA).
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  • Chunhai Fan

    Corresponding author
    1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800 (P. R. China)
    • Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800 (P. R. China)
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Abstract

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A 3D DNA nanostructure-based sensor platform for DNA detection has been developed. This strategy provides significantly enhanced spatial positioning range and accessibility of the probes on a surface over previously reported DNA sensing architectures. The use of this versatile DNA nanostructure-based detection platform leads to highly sensitive and selective DNA detection in biological fluids and greatly enhanced sequence specificity for SNP typing.

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