Advanced Materials

A Modular, Hydroxyapatite-Binding Version of Vascular Endothelial Growth Factor

Authors

  • Jae Sung Lee,

    1. Department of Biomedical Engineering, University of Wisconsin, 1550 Engineering Drive, Madison, WI 53706 (USA)
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  • Amy J. Wagoner Johnson,

    1. Department of Mechanical Science and Engineering, University of Illinois, 1206 West Green Street, Urbana, IL 61801 (USA)
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  • William L. Murphy

    Corresponding author
    1. Department of Biomedical Engineering, University of Wisconsin, 1550 Engineering Drive, Madison, WI 53706 (USA)
    2. Department of Orthopedics and Rehabilitation, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792 (USA)
    3. Department of Pharmacology, University of Wisconsin, 1300 University Avenue, Madison, WI 53706 (USA)
    4. Collaborative Research Center, AO Foundation
    • Department of Biomedical Engineering, University of Wisconsin, 1550 Engineering Drive, Madison, WI 53706 (USA).
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Abstract

We report a modular peptide that mimics the pro-angiogenic properties of vascular endothelial growth factor and the hydroxyapatite-binding ability of bone protein osteocalcin. It binds rapidly and efficiently to hydroxyapatite, and locally induces early pro-angiogenic activities, including endothelial cell proliferation and migration both when it exists in a soluble form and when it is immobilized on a hydroxyapatite biomaterial.

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