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Surface Functionalization of Porous Coordination Nanocages Via Click Chemistry and Their Application in Drug Delivery

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Abstract

Porous coordination nanocages covered with alkyne groups are synthesized through judicious selection of the ligand and reaction conditions. The surface functionalization via click reaction with azide-terminated polyethylene glycol turns them into water-stable colloids, which exhibit controlled release of an anticancer drug 5-fluorouracil.

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