Bypassing Multidrug Resistance in Cancer Cells with Biodegradable Polymer Capsules

Authors

  • Yan Yan,

    1. Centre for Nanoscience and Nanotechnology, Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010 (Australia)
    Search for more papers by this author
  • Christopher J. Ochs,

    1. Centre for Nanoscience and Nanotechnology, Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010 (Australia)
    Search for more papers by this author
  • Georgina K. Such,

    1. Centre for Nanoscience and Nanotechnology, Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010 (Australia)
    Search for more papers by this author
  • Joan K. Heath,

    1. Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria 3050 (Australia)
    Search for more papers by this author
  • Edouard C. Nice,

    1. Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria 3050 (Australia)
    2. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800 (Australia)
    Search for more papers by this author
  • Frank Caruso

    Corresponding author
    1. Centre for Nanoscience and Nanotechnology, Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010 (Australia)
    • Centre for Nanoscience and Nanotechnology, Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010 (Australia).
    Search for more papers by this author

Abstract

original image

Biodegradable polymer capsules with drug-loaded multilayers were prepared through click chemistry via layer-by-layer assembly. The capsules can efficiently release incorporated drug by intracellular enzymatic degradation in both sensitive and resistant colorectal cancer cells in vitro. Endocytosis of drug-loaded capsules leads to bypass of Pgp-mediated multidrug resistance in cancer cells.

Ancillary