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Elastomeric Electrospun Polyurethane Scaffolds: The Interrelationship Between Fabrication Conditions, Fiber Topology, and Mechanical Properties

Authors

  • Nicholas J. Amoroso,

    1. Department of Bioengineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
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  • Antonio D’Amore,

    1. Dipartimento di Meccanica, University of Palermo (Italy), Department of Bioengineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
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  • Yi Hong,

    1. Department of Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
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  • William R. Wagner,

    1. Departments of Surgery, Bioengineering, and Chemical Engineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
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  • Michael S. Sacks

    Corresponding author
    1. Department of Bioengineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    • Department of Bioengineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.
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Abstract

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Elastomeric electrospun constructfabrication conditions are evaluated with regard to their effect on fiber topology and biaxial mechanical response. It is determined that fiber alignment alone is insufficient to predict mechanical response. Moreover, fiber intersection density is introduced as a quantifiable structural measure that can be manipulated to achieve mechanical anisotropy similar to that of native soft tissues.

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