Self-Assembled DNA Hydrogels with Designable Thermal and Enzymatic Responsiveness



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An easy and versatile approach to construct DNA hydrogels is reported. The DNA building blocks, a Y-scaffold and a linker, can self-assemble into DNA hydrogels by the hybridization of their “sticky ends”. It is shown that the DNA hydrogels undergo a sol-gel transition upon heat or enzymatic treatment, and these responsiveness can be adjusted by tailoring the sequence of the building blocks.