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A Novel Family of Biodegradable Poly(ester amide) Elastomers

Authors

  • Hao Cheng,

    1. D. H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    2. Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
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  • Paulina S. Hill,

    1. D. H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
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  • Daniel J. Siegwart,

    1. D. H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
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  • Nathaniel Vacanti,

    1. D. H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
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  • Abigail K. R. Lytton-Jean,

    1. D. H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
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  • Seung-Woo Cho,

    1. Department of Biotechnology, Yonsei University, Seoul 120-749, Korea
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  • Anne Ye,

    1. D. H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
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  • Robert Langer,

    1. D. H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    2. Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    3. Division of Health Science Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
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  • Daniel G. Anderson

    Corresponding author
    1. D. H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    2. Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    3. Division of Health Science Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    • D. H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
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Abstract

Biodegradable elastomeric materials have particular utility in tissue engineering applications because their compliance under force closely resembles the elastic nature of many human tissues. A family of biodegradable poly(ester amide) elastomers were developed, with excellent elasticity under hydrated conditions, good in vivo biocompatibility and a slow degradation rate. This study sheds light on the structure-property relationship behind designing biodegradable elastomeric materials.

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