Design and In Situ Characterization of Lipid Containers with Enhanced Drug Retention

Authors

  • Benjamin Wong,

    1. Departments of Chemical Engineering and Materials, University of California, Santa Barbara, Santa Barbara, California, 93106, USA
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  • Cecile Boyer,

    1. Departments of Chemical Engineering and Materials, University of California, Santa Barbara, Santa Barbara, California, 93106, USA
    Current affiliation:
    1. Present adress: The Dow Chemical Company, Freeport, Texas 77566, USA
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  • Christian Steinbeck,

    1. Departments of Chemical Engineering and Materials, University of California, Santa Barbara, Santa Barbara, California, 93106, USA
    Current affiliation:
    1. Present adress: The Dow Chemical Company, Freeport, Texas 77566, USA
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  • David Peters,

    1. Departments of Chemical Engineering and Materials, University of California, Santa Barbara, Santa Barbara, California, 93106, USA
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  • Jason Schmidt,

    1. Departments of Chemical Engineering and Materials, University of California, Santa Barbara, Santa Barbara, California, 93106, USA
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  • Ryan van Zanten,

    1. Departments of Chemical Engineering and Materials, University of California, Santa Barbara, Santa Barbara, California, 93106, USA
    Current affiliation:
    1. Present adress: Halliburton, 3000 N Sam Houston Pkwy E, Houston, TX 77032, USA
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  • Bradley Chmelka,

    1. Departments of Chemical Engineering and Materials, University of California, Santa Barbara, Santa Barbara, California, 93106, USA
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  • Joseph A. Zasadzinski

    Corresponding author
    1. Departments of Chemical Engineering and Materials, University of California, Santa Barbara, Santa Barbara, California, 93106, USA
    • Departments of Chemical Engineering and Materials, University of California, Santa Barbara, Santa Barbara, California, 93106, USA.
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Abstract

original image

Vesosome with distinct interior (green, orange) and exterior (blue) bilayer membranes. Drugs are encapsulated within the interior compartments and are protected from blood serum components by the exterior membrane. The outer membrane can be decorated with PEG lipids (red) to prevent aggregation in the blood as well as specific labels or targeting ligands.

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