Doxorubicin Release Triggered by Alginate Embedded Magnetic Nanoheaters: A Combined Therapy



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Alginate microbeads with iron oxide nanoparticle heaters that carry doxo-rubicin are investigated in vitro for simultaneous drug targeting and local heat generation (hyperthermia). Application of an alternative magnetic field (AMF) causes magnetic-hyperthermia-enhanced doxorubicin release. The AMF-triggered drug release and hyperthermia exhibit synergistic effects and result in significant tumor cell death.