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Advanced Materials

Oppositely Charged Gelatin Nanospheres as Building Blocks for Injectable and Biodegradable Gels

Authors

  • Huanan Wang,

    1. Department of Biomaterials, Radboud University Nijmegen Medical Center, Philips van Leydenlaan 25, 6525 EX Nijmegen, The Netherlands
    2. Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, 610064 Chengdu, P. R. China
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  • Morten B. Hansen,

    1. Department of Bio-organic Chemistry, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands
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  • Dennis W. P. M. Löwik,

    1. Department of Bio-organic Chemistry, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands
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  • Jan C. M. van Hest,

    1. Department of Bio-organic Chemistry, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands
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  • Yubao Li,

    1. Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, 610064 Chengdu, P. R. China
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  • John A. Jansen,

    1. Department of Biomaterials, Radboud University Nijmegen Medical Center, Philips van Leydenlaan 25, 6525 EX Nijmegen, The Netherlands
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  • Sander C. G. Leeuwenburgh

    Corresponding author
    1. Department of Biomaterials, Radboud University Nijmegen Medical Center, Philips van Leydenlaan 25, 6525 EX Nijmegen, The Netherlands
    • Department of Biomaterials, Radboud University Nijmegen Medical Center, Philips van Leydenlaan 25, 6525 EX Nijmegen, The Netherlands.
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Abstract

Injectable and biodegradable gels have been formed by a bottom-up synthesis strategy employing oppositely charged gelatin nanospheres as particulate building blocks. These gels are formed by electrostatic interactions between and tight packing of gelatin nanospheres of opposite charge. Due to their favorable clinical handling, ease of functionalization, and cost-effectiveness, these gels show great potential as injectable gels for tissue regeneration.

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