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Keywords:

  • polymeric nanoparticles;
  • PLGA-PEG;
  • nanoprecipitation;
  • 3D hydrodynamic focusing;
  • microfluidic
Thumbnail image of graphical abstract

A versatile microfluidic platform to synthesize NPs by nanoprecipitation using 3D hydrodynamic flow focusing isolates the precipitating precursors from channel walls, eliminating fouling of the channels. It is shown that this new method enables robust nanoprecipitation without polymer aggregation, regardless of the polymer molecular weight or precursor concentration implemented, where the size of the resulting polymeric NPs is tunable.