M.R. and P.M.V. contributed equally to this work.
Communication “Advanced Healthcare Materials”
Synthesis of Size-Tunable Polymeric Nanoparticles Enabled by 3D Hydrodynamic Flow Focusing in Single-Layer Microchannels†
Article first published online: 22 FEB 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 23, Issue 12, pages H79–H83, March 25, 2011
How to Cite
Rhee, M., Valencia, P. M., Rodriguez, M. I., Langer, R., Farokhzad, O. C. and Karnik, R. (2011), Synthesis of Size-Tunable Polymeric Nanoparticles Enabled by 3D Hydrodynamic Flow Focusing in Single-Layer Microchannels. Adv. Mater., 23: H79–H83. doi: 10.1002/adma.201004333
- Issue published online: 23 MAR 2011
- Article first published online: 22 FEB 2011
- Manuscript Revised: 23 DEC 2010
- Manuscript Received: 24 NOV 2010
- polymeric nanoparticles;
- 3D hydrodynamic focusing;
A versatile microfluidic platform to synthesize NPs by nanoprecipitation using 3D hydrodynamic flow focusing isolates the precipitating precursors from channel walls, eliminating fouling of the channels. It is shown that this new method enables robust nanoprecipitation without polymer aggregation, regardless of the polymer molecular weight or precursor concentration implemented, where the size of the resulting polymeric NPs is tunable.