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Advanced Materials

Synthesis of Size-Tunable Polymeric Nanoparticles Enabled by 3D Hydrodynamic Flow Focusing in Single-Layer Microchannels

Authors

  • Minsoung Rhee,

    1. Department of Mechanical Engineering Massachusetts, Institute of Technology, Cambridge, MA 02139, USA
    2. Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women’s Hospital Harvard Medical School Boston, MA 02115, USA
    3. David H. Koch Institute for Integrative Cancer Research Massachusetts, Institute of Technology, Cambridge, MA 02139, USA
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  • Pedro M. Valencia,

    1. Department of Chemical Engineering Massachusetts, Institute of Technology, Cambridge, MA 02139, USA
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  • Maria I. Rodriguez,

    1. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
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  • Robert Langer,

    1. David H. Koch Institute for Integrative Cancer Research Massachusetts, Institute of Technology, Cambridge, MA 02139, USA
    2. Department of Chemical Engineering Massachusetts, Institute of Technology, Cambridge, MA 02139, USA
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  • Omid C. Farokhzad,

    Corresponding author
    1. Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women’s Hospital Harvard Medical School Boston, MA 02115, USA
    • Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women’s Hospital Harvard Medical School Boston, MA 02115, USA
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  • Rohit Karnik

    Corresponding author
    1. Department of Mechanical Engineering Massachusetts, Institute of Technology, Cambridge, MA 02139, USA
    • Department of Mechanical Engineering Massachusetts, Institute of Technology, Cambridge, MA 02139, USA.
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  • M.R. and P.M.V. contributed equally to this work.

Abstract

A versatile microfluidic platform to synthesize NPs by nanoprecipitation using 3D hydrodynamic flow focusing isolates the precipitating precursors from channel walls, eliminating fouling of the channels. It is shown that this new method enables robust nanoprecipitation without polymer aggregation, regardless of the polymer molecular weight or precursor concentration implemented, where the size of the resulting polymeric NPs is tunable.

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