Communication “Advanced Healthcare Materials”

Molding Cell Beads for Rapid Construction of Macroscopic 3D Tissue Architecture

  1. Yukiko T. Matsunaga1,2,†,
  2. Yuya Morimoto1,†,
  3. Shoji Takeuchi1,2,*

Article first published online: 1 MAR 2011

DOI: 10.1002/adma.201004375

Issue

Advanced Materials

Advanced Materials

Volume 23, Issue 12, pages H90–H94, March 25, 2011

Additional Information

How to Cite

Matsunaga, Y. T., Morimoto, Y. and Takeuchi, S. (2011), Molding Cell Beads for Rapid Construction of Macroscopic 3D Tissue Architecture. Advanced Materials, 23: H90–H94. doi: 10.1002/adma.201004375

Author Information

  1. 1

    Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan

  2. 2

    Life BEANS Center, BEANS Project, 4 – 6-1 Komaba, Meguro-ku, Tokyo 153 – 8505, Japan

  1. †

    Y. T. M and Y. M. contributed equally to this work.

*Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan.

Publication History

  1. Issue published online: 23 MAR 2011
  2. Article first published online: 1 MAR 2011
  3. Manuscript Received: 27 NOV 2010

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (757K)

Keywords:

  • tissue engineering;
  • collagen gel beads;
  • microfluidic system

Graphical Abstract

Thumbnail image of graphical abstract

A microfluidic system was used to prepare a large number of size-controlled collagen gel beads to form microtissue units, “cell beads”, as tissue building blocks. By stacking cell beads into a doll-shaped silicone chamber, millimeter-thick tissue with uniform cell density was formed rapidly. The bead structure allowed the application into the 3D printing, achieving automated geometrical control of the formed tissues for the fabrication of functional complex tissues.

View Full Article with Supporting Information (HTML) Get PDF (757K)