Elastic 3D Scaffolds: Elastic Fully Three-dimensional Microstructure Scaffolds for Cell Force Measurements (Adv. Mater. 8/2010)

Authors

  • Franziska Klein,

    1. Zoologisches Institut, Zell- und Neurobiologie Universität Karlsruhe (TH) Haid-und-Neu-Straße 9, D-76131 Karlsruhe (Germany)
    2. DFG-Center for Functional Nanostructures (CFN) Universität Karlsruhe (TH) Wolfgang-Gaede-Straße 1, D-76131 Karlsruhe (Germany)
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  • Thomas Striebel,

    1. DFG-Center for Functional Nanostructures (CFN) and Institut für Angewandte Physik Universität Karlsruhe (TH) Wolfgang-Gaede-Straße 1, D-76131 Karlsruhe (Germany)
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  • Joachim Fischer,

    1. DFG-Center for Functional Nanostructures (CFN) and Institut für Angewandte Physik Universität Karlsruhe (TH) Wolfgang-Gaede-Straße 1, D-76131 Karlsruhe (Germany)
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  • Zhongxiang Jiang,

    1. Zoologisches Institut, Zell- und Neurobiologie Universität Karlsruhe (TH) Haid-und-Neu-Straße 9, D-76131 Karlsruhe (Germany)
    2. DFG-Center for Functional Nanostructures (CFN) Universität Karlsruhe (TH) Wolfgang-Gaede-Straße 1, D-76131 Karlsruhe (Germany)
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  • Clemens M. Franz,

    1. DFG-Center for Functional Nanostructures (CFN) Universität Karlsruhe (TH) Wolfgang-Gaede-Straße 1, D-76131 Karlsruhe (Germany)
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  • Georg von Freymann,

    1. DFG-Center for Functional Nanostructures (CFN) and Institut für Angewandte Physik Universität Karlsruhe (TH) Wolfgang-Gaede-Straße 1, D-76131 Karlsruhe (Germany)
    2. Institut für Nanotechnologie Forschungszentrum Karlsruhe in der Helmholtz-Gemeinschaft D-76021 Karlsruhe (Germany)
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  • Martin Wegener,

    1. DFG-Center for Functional Nanostructures (CFN) and Institut für Angewandte Physik Universität Karlsruhe (TH) Wolfgang-Gaede-Straße 1, D-76131 Karlsruhe (Germany)
    2. Institut für Nanotechnologie Forschungszentrum Karlsruhe in der Helmholtz-Gemeinschaft D-76021 Karlsruhe (Germany)
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  • Martin Bastmeyer

    Corresponding author
    1. Zoologisches Institut, Zell- und Neurobiologie Universität Karlsruhe (TH) Haid-und-Neu-Straße 9, D-76131 Karlsruhe (Germany)
    • Zoologisches Institut, Zell- und Neurobiologie Universität Karlsruhe (TH) Haid-und-Neu-Straße 9, D-76131 Karlsruhe (Germany).
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Abstract

original image

Martin Bastmeyer and co-workers report on p. 868 the fabrication of elastic structures with submicrometer thickness for cell culture that can be deformed by forces exerted by single cardiomyocytes. The cover illustrates a 3D reconstruction of cardiomyocytes labeled for f-actin (green) and a-actinin (red) growing in an Ormocomp scaffold consisting of posts connected by flexible beams. This method offers the possibility to study cell behavior in a 3D environment with defined geometries and physiologically-relevant stiffness values. Cover artwork by M.S. Rill.

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