Martin Bastmeyer and co-workers report on p. 868 the fabrication of elastic structures with submicrometer thickness for cell culture that can be deformed by forces exerted by single cardiomyocytes. The cover illustrates a 3D reconstruction of cardiomyocytes labeled for f-actin (green) and a-actinin (red) growing in an Ormocomp scaffold consisting of posts connected by flexible beams. This method offers the possibility to study cell behavior in a 3D environment with defined geometries and physiologically-relevant stiffness values. Cover artwork by M.S. Rill.