Drug Delivery: Nano-Layered Microneedles for Transcutaneous Delivery of Polymer Nanoparticles and Plasmid DNA (Adv. Mater. 43/2010)

Authors

  • Peter C. DeMuth,

    1. Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139 (USA)
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  • Xingfang Su,

    1. Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139 (USA)
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  • Raymond E. Samuel,

    1. Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139 (USA)
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  • Paula T. Hammond,

    Corresponding author
    1. Department of Chemical Engineering and Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139 (USA)
    • Department of Chemical Engineering and Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139 (USA).
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  • Darrell J. Irvine

    Corresponding author
    1. Department of Materials Science and Engineering, Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139 (USA), Ragon Institute of MIT, MGH, and Harvard Boston, MA 02139, Howard Hughes Medical Institute, 4000 Jones Bridge Rd., Chevy Chase, MD
    • Department of Materials Science and Engineering, Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139 (USA), Ragon Institute of MIT, MGH, and Harvard Boston, MA 02139, Howard Hughes Medical Institute, 4000 Jones Bridge Rd., Chevy Chase, MD
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Abstract

original image

A new strategy to create biodegradable drug-loaded coatings on microneedle patches, using a process known as layer-by-layer (LbL) self-assembly, is reported on p. 4851 by Paula Hammond and coworkers. Water-soluble polymers are adsorbed with oppositely-charged drugs or drug-carrying polymer particles in alternating layers, creating extremely thin coatings loaded with high levels of entrapped drugs. These biodegradable films can be used to deposit DNA or drug-carrier nanoparticles into the skin, representing model drug cargos that could be used for vaccination or other therapeutic drug delivery.

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