Advanced Materials

Stem Cells: Patterned Differentiation of Individual Embryoid Bodies in Spatially Organized 3D Hybrid Microgels (Adv. Mater. 46/2010)

Authors

  • Hao Qi,

    1. Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, (USA), Telephone: 1 – 617-768 — 8395, Fax: 1 – 617-768 — 8477
    2. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, (USA)
    Search for more papers by this author
  • Yanan Du,

    1. Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, (USA), Telephone: 1 – 617-768 — 8395, Fax: 1 – 617-768 — 8477
    2. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, (USA)
    3. Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, (China)
    Search for more papers by this author
  • Lianyong Wang,

    1. Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, (USA), Telephone: 1 – 617-768 — 8395, Fax: 1 – 617-768 — 8477
    2. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, (USA)
    3. Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin, (China)
    Search for more papers by this author
  • Hirokazu Kaji,

    1. Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, (USA), Telephone: 1 – 617-768 — 8395, Fax: 1 – 617-768 — 8477
    2. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, (USA)
    3. Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, Sendai, (Japan)
    Search for more papers by this author
  • Hojae Bae,

    1. Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, (USA), Telephone: 1 – 617-768 — 8395, Fax: 1 – 617-768 — 8477
    2. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, (USA)
    Search for more papers by this author
  • Ali Khademhosseini

    Corresponding author
    1. Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, (USA), Telephone: 1 – 617-768 — 8395, Fax: 1 – 617-768 — 8477
    2. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, (USA)
    • Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, (USA), Telephone: 1 – 617-768 — 8395, Fax: 1 – 617-768 — 8477.
    Search for more papers by this author

Abstract

A microengineered hybrid hydrogel containing asymmetrical extracellular matrices is developed to mimic anisotropic stem cell niches, in work reported by Ali Khademhosseini and co-workers on p. 5276. The reconstructed artificial asymmetrical extracellular matrix enables thorough investigation of spatially regulated embryonic development without exogenous factors. This technique may be a powerful platform for further understanding and engineering of stem cells in controlled environments.

original image

Ancillary