Advanced Materials

Drug Delivery: Bypassing Multidrug Resistance in Cancer Cells with Biodegradable Polymer Capsules (Adv. Mater. 47/2010)

Authors

  • Yan Yan,

    1. Centre for Nanoscience and Nanotechnology, Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010 (Australia)
    Search for more papers by this author
  • Christopher J. Ochs,

    1. Centre for Nanoscience and Nanotechnology, Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010 (Australia)
    Search for more papers by this author
  • Georgina K. Such,

    1. Centre for Nanoscience and Nanotechnology, Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010 (Australia)
    Search for more papers by this author
  • Joan K. Heath,

    1. Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria 3050 (Australia)
    Search for more papers by this author
  • Edouard C. Nice,

    1. Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria 3050 (Australia)
    2. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800 (Australia)
    Search for more papers by this author
  • Frank Caruso

    Corresponding author
    1. Centre for Nanoscience and Nanotechnology, Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010 (Australia)
    • Centre for Nanoscience and Nanotechnology, Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010 (Australia).
    Search for more papers by this author

Abstract

The inside cover illustrates a pathway to bypass Pgp-mediated multidrug resistance in cancer cells through endocytosis of microcapsules (right), compared with drug effluxing (left), as reported in work by Frank Caruso and co-workers on p. 5398. Biodegradable polymer capsules conjugated with drug were prepared through click chemistry via layer-by-layer assembly. The incorporated drug is subsequently released after the internalization of microcapsules by intracellular enzymatic environment. This approach opens a generic way to challenge Pgp-mediated multidrug resistance.

original image

Ancillary