Mineral Coatings for Temporally Controlled Delivery of Multiple Proteins

Authors

  • Jae Sung Lee,

    1. Department of Biomedical Engineering, University of Wisconsin, 1550 Engineering Drive, Madison, WI 53706, USA
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  • Darilis Suarez-Gonzalez,

    1. Materials Science Program, University of Wisconsin, 1509 University Avenue, Madison, WI 53706, USA
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  • William L. Murphy

    Corresponding author
    1. Department of Biomedical Engineering, University of Wisconsin, 1550 Engineering Drive, Madison, WI 53706, USA
    2. Department of Orthopedics and Rehabilitation, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA
    3. Department of Pharmacology, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA
    4. Collaborative Research Center, AO Foundation. Davos, Switzerland
    • Department of Biomedical Engineering, University of Wisconsin, 1550 Engineering Drive, Madison, WI 53706, USA.
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Abstract

original image

Mineral coatings are presented as a temporally controllable protein release system on a common orthopedic device material, β-tricalcium phosphate (β-TCP). Proteins are bound to coatings via electrostatic interactions and release of one or more proteins is temporally controlled in a predictable manner by modulating the physicochemical properties of mineral coatings, including morphology and dissolution rate.

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