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pH-Triggered Drug-Releasing Magnetic Nanoparticles for Cancer Therapy Guided by Molecular Imaging by MRI

Authors

  • Eun-Kyung Lim,

    1. Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, Republic of Korea
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  • Yong-Min Huh,

    1. Department of Radiology, Yonsei University, Seoul 120-752, Republic of Korea
    2. YUHS-KRIBB Medical Convergence Research Institute, Seoul 120-752, Republic of Korea
    3. Severance Biomedical Science Institute(SBSI), Seoul 120-752, Republic of Korea
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  • Jaemoon Yang,

    1. Department of Radiology, Yonsei University, Seoul 120-752, Republic of Korea
    2. YUHS-KRIBB Medical Convergence Research Institute, Seoul 120-752, Republic of Korea
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  • Kwangyeol Lee,

    1. Department of Chemistry, Korea University, Seoul 136-701, Republic of Korea
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  • Jin-Suck Suh,

    Corresponding author
    1. Department of Radiology, Yonsei University, Seoul 120-752, Republic of Korea
    2. YUHS-KRIBB Medical Convergence Research Institute, Seoul 120-752, Republic of Korea
    3. Severance Biomedical Science Institute(SBSI), Seoul 120-752, Republic of Korea
    • Department of Radiology, Yonsei University, Seoul 120-752, Republic of Korea
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  • Seungjoo Haam

    Corresponding author
    1. Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, Republic of Korea
    2. YUHS-KRIBB Medical Convergence Research Institute, Seoul 120-752, Republic of Korea
    • Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, Republic of Korea.
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Abstract

pH-sensitive drug-delivering magnetic nanoparticles (DMNPs) have been developed as theragnostic nanocarriers that release doxorubicin (DOX) under acidic conditions within cancer cells. The drug release kinetics of the DMNPs, combined with the nanoparticle accumulation pattern in tumor cells, can be monitored by magnetic resonance imaging (MRI) to guide decisions regarding the optimization of drug dosing schedules.

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