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Development of Cationic Polymer Coatings to Regulate Foreign-Body Responses

Authors

  • Minglin Ma,

    1. David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
    2. Department of Anesthesiology, Children Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
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  • Wendy F. Liu,

    1. David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
    2. Department of Anesthesiology, Children Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
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  • Paulina S. Hill,

    1. David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
    2. Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
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  • Kaitlin M. Bratlie,

    1. David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
    2. Department of Anesthesiology, Children Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
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  • Daniel J. Siegwart,

    1. David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
    2. Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
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  • Justin Chin,

    1. Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
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  • Miri Park,

    1. David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
    2. Department of Anesthesiology, Children Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
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  • Joao Guerreiro,

    1. David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
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  • Daniel G. Anderson

    Corresponding author
    1. David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
    2. Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
    3. Division of Health Science Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA
    4. Department of Anesthesiology, Children Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    • David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.
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Abstract

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A library of cationic polymers, poly(beta-amino alcohols) with a great chemical diversity are synthesized using combinatorial polymerization. These polymers, when immobilized on a surface, drastically affect the behavior of monocyte/macrophage cells in vitro and early inflammatory reactions in vivo. Certain polymers are found capable of mitigating the foreign-body responses.

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