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Hydrophobic Shell Loading of Biopolyelectrolyte Capsules

Authors

  • Di Cui,

    1. Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS), affiliated with Université Joseph Fourier, and member of the Institut de Chimie Moléculaire de Grenoble, France
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  • Jing Jing,

    1. Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS), affiliated with Université Joseph Fourier, and member of the Institut de Chimie Moléculaire de Grenoble, France
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  • Thomas Boudou,

    1. Minatec, Grenoble Institute of Technology, LMGP, CNRS, 3 parvis Louis Néel, 38 016 Grenoble, France
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  • Isabelle Pignot-Paintrand,

    1. Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS), affiliated with Université Joseph Fourier, and member of the Institut de Chimie Moléculaire de Grenoble, France
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  • Stefaan De Koker,

    1. Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
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  • Bruno G. De Geest,

    1. Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
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  • Catherine Picart,

    Corresponding author
    1. Minatec, Grenoble Institute of Technology, LMGP, CNRS, 3 parvis Louis Néel, 38 016 Grenoble, France
    • Minatec, Grenoble Institute of Technology, LMGP, CNRS, 3 parvis Louis Néel, 38 016 Grenoble, France.
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  • Rachel Auzély-Velty

    Corresponding author
    1. Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS), affiliated with Université Joseph Fourier, and member of the Institut de Chimie Moléculaire de Grenoble, France
    • Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS), affiliated with Université Joseph Fourier, and member of the Institut de Chimie Moléculaire de Grenoble, France
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Abstract

A versatile method to selectively encapsulate water-insoluble molecules in the nanoshell of layer-by-layer capsules made exclusively of polysaccharides is described. This relies on the very high affinity of hydrophobic molecules for an alkylated hyaluronic acid used as a polyanionic partner of a chitosan derivative for the capsule synthesis. The hydrophobic molecules entrapped in the nanoshell can be delivered intracellularly in dendritic cells.

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