Facile Engineering of Biocompatible Materials with pH-Modulated Degradability

Authors

  • Jianxiang Zhang,

    Corresponding author
    1. Department of Pharmaceutics, College of Pharmacy, Third Military Medical University, Chongqing 400038, P. R. China
    • Department of Pharmaceutics, College of Pharmacy, Third Military Medical University, Chongqing 400038, P. R. China.
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  • Yi Jia,

    1. Department of Pharmaceutics, College of Pharmacy, Third Military Medical University, Chongqing 400038, P. R. China
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  • Xiaodong Li,

    1. Affiliated Stomatology Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, P. R. China
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  • Yingqian Hu,

    1. Key Laboratory of Organosilicon Chemistry and Material, Technology of Ministry of Education, Hangzhou Normal University Hangzhou 310012, P. R. China
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  • Xiaohui Li

    Corresponding author
    1. Department of Pharmaceutics, College of Pharmacy, Third Military Medical University, Chongqing 400038, P. R. China
    • Department of Pharmaceutics, College of Pharmacy, Third Military Medical University, Chongqing 400038, P. R. China.
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Abstract

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Facile synthesis of biocompatible materials from α- or β-cyclodextrin and their polymers can be achieved via a kinetically controlled acetalation. These materials can hydrolyze into the corresponding precursors, with a fast or slow process dependent on pH. Since cyclodextrins can function as the building units to synthesize polymers with great structural diversity, the methodology developed herein may be a facile but powerful approach to create a materials library with wide biomedical applications.

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