Communication

Dynamic Topographical Control of Mesenchymal Stem Cells by Culture on Responsive Poly(ϵ-caprolactone) Surfaces

  1. Duy M. Le1,
  2. Karina Kulangara2,
  3. Andrew F. Adler2,
  4. Kam W. Leong2,
  5. Valerie Sheares Ashby1,*

Article first published online: 30 MAY 2011

DOI: 10.1002/adma.201100821

Issue

Advanced Materials

Advanced Materials

Volume 23, Issue 29, pages 3278–3283, August 2, 2011

Additional Information

How to Cite

Le, D. M., Kulangara, K., Adler, A. F., Leong, K. W. and Ashby, V. S. (2011), Dynamic Topographical Control of Mesenchymal Stem Cells by Culture on Responsive Poly(ϵ-caprolactone) Surfaces. Adv. Mater., 23: 3278–3283. doi: 10.1002/adma.201100821

Author Information

  1. 1

    Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA

  2. 2

    Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA

*Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA.

Publication History

  1. Issue published online: 27 JUL 2011
  2. Article first published online: 30 MAY 2011
  3. Manuscript Revised: 22 APR 2011
  4. Manuscript Received: 2 MAR 2011

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Keywords:

  • shape-memory polymers;
  • dynamic cell culture;
  • surface topography;
  • mesenchymal stem cells;
  • polycaprolactone
Thumbnail image of graphical abstract

Poly(ϵ-caprolactone) (PCL) shape-memory polymer (SMP) microarrays are a novel means to investigate the effect of dynamic topography on human mesenchymal stem cell (hMSC) morphology. The synthesis and characterization of oligo-precursors and PCL networks is described. The PCL surfaces demonstrate excellent surface shape-memory properties, minimal cytotoxicity, and excellent control over hMSC morphology.

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