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Dynamic Topographical Control of Mesenchymal Stem Cells by Culture on Responsive Poly(ϵ-caprolactone) Surfaces



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Poly(ϵ-caprolactone) (PCL) shape-memory polymer (SMP) microarrays are a novel means to investigate the effect of dynamic topography on human mesenchymal stem cell (hMSC) morphology. The synthesis and characterization of oligo-precursors and PCL networks is described. The PCL surfaces demonstrate excellent surface shape-memory properties, minimal cytotoxicity, and excellent control over hMSC morphology.