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Directed Blood Vessel Growth Using an Angiogenic Microfiber/Microparticle Composite Patch

Authors

  • Ross J. DeVolder,

    1. Department of Chemical and Biomolecular Engineering, Institute for Genomic Biology, University of Illinois, 600 South Mathews Avenue, Urbana, IL 61801, USA
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  • Harim Bae,

    1. Department of Chemical Engineering and Materials Science, Chung-Ang University, 221 Heukseok-dong, Dongjak-gu, Seoul 156-756, Korea (South)
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  • Jonghwi Lee,

    Corresponding author
    1. Department of Chemical Engineering and Materials Science, Chung-Ang University, 221 Heukseok-dong, Dongjak-gu, Seoul 156-756, Korea (South)
    • Department of Chemical Engineering and Materials Science, Chung-Ang University, 221 Heukseok-dong, Dongjak-gu, Seoul 156-756, Korea (South)
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  • Hyunjoon Kong

    Corresponding author
    1. Department of Chemical and Biomolecular Engineering, Institute for Genomic Biology, University of Illinois, 600 South Mathews Avenue, Urbana, IL 61801, USA
    • Department of Chemical and Biomolecular Engineering, Institute for Genomic Biology, University of Illinois, 600 South Mathews Avenue, Urbana, IL 61801, USA.
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Abstract

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An angiogenic microfiber patch that releases angiogenic growth factors along aligned fibers and subsequently directs the spacing and orientation of mature and functional blood vessel formation is presented. The fiber patches are prepared by electrostatically binding electrosprayed vascular endothelial growth factor (VEGF)-encapsulating poly(lactide-co-glycolide) (PLGA) microparticles with electrospun poly(lactide) (PLA) microfibers.

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