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Synthesis and Radioluminescence of PEGylated Eu3+-doped Nanophosphors as Bioimaging Probes

Authors

  • Conroy Sun,

    1. Molecular Imaging Program at Stanford, Stanford University, Stanford, CA 94305, USA
    2. Department of Radiation Oncology, School of Medicine, Stanford University Stanford, CA 94305, USA
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  • Guillem Pratx,

    1. Molecular Imaging Program at Stanford, Stanford University, Stanford, CA 94305, USA
    2. Department of Radiation Oncology, School of Medicine, Stanford University Stanford, CA 94305, USA
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  • Colin M. Carpenter,

    1. Molecular Imaging Program at Stanford, Stanford University, Stanford, CA 94305, USA
    2. Department of Radiation Oncology, School of Medicine, Stanford University Stanford, CA 94305, USA
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  • Hongguang Liu,

    1. Molecular Imaging Program at Stanford, Stanford University, Stanford, CA 94305, USA
    2. Department of Radiology, School of Medicine, Stanford University, Stanford, CA 94305, USA
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  • Zhen Cheng,

    1. Molecular Imaging Program at Stanford, Stanford University, Stanford, CA 94305, USA
    2. Department of Radiology, School of Medicine, Stanford University, Stanford, CA 94305, USA
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  • Sanjiv Sam Gambhir,

    1. Molecular Imaging Program at Stanford, Stanford University, Stanford, CA 94305, USA
    2. Department of Radiology, School of Medicine, Stanford University, Stanford, CA 94305, USA
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  • Lei Xing

    Corresponding author
    1. Molecular Imaging Program at Stanford, Stanford University, Stanford, CA 94305, USA
    2. Department of Radiation Oncology, School of Medicine, Stanford University Stanford, CA 94305, USA
    • Molecular Imaging Program at Stanford, Stanford University, Stanford, CA 94305, USA.
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Abstract

Lanthanide-doped nanophosphors stimu­lated by high-energy photons or β+-particles display characteristic 590, 615, and 692 nm emissions of the Eu3+ activator. These radioluminescent nanophosphors, produced by a thermo degradation process and coated with poly(ethylene glycol), serve as imaging probes as demonstrated in vivo with matrigel inclusions detected by both a custom X-ray luminescence and a conventional small animal optical imaging system.

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