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Clay Gels For the Delivery of Regenerative Microenvironments

Authors

  • Jonathan I. Dawson,

    1. Bone and Joint Research, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD, UK
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  • Janos M. Kanczler,

    1. Bone and Joint Research, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD, UK
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  • Xuebin B. Yang,

    1. Division of Oral Biology, University of Leeds, Leeds, LS2 9LU, UK
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  • George S. Attard,

    1. School of Chemistry, University of Southampton, Southampton, SO17 1BJ, UK
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  • Richard O.C. Oreffo

    Corresponding author
    1. Bone and Joint Research, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD, UK
    • Bone and Joint Research, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD, UK.
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Abstract

The sorptive properties of clay are harnessed to provide niches for tissue regeneration. Synthetic smectite clays self-organize into gels under physiological conditions to allow encapsulation of cells and demonstrate remarkable capacity for the localization of biological molecules without the need for complex chemical modifications.

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