Nanofibrous Lipid Membranes Capable of Functionally Immobilizing Antibodies and Capturing Specific Cells

Authors

  • Zhengbao Zha,

    1. Department of Aerospace and Mechanical Engineering, Biomedical Engineering IDP and Bio5 Institute, University of Arizona, Tucson, Arizona 85721, USA
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  • Celine Cohn,

    1. Department of Aerospace and Mechanical Engineering, Biomedical Engineering IDP and Bio5 Institute, University of Arizona, Tucson, Arizona 85721, USA
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  • Zhifei Dai,

    Corresponding author
    1. Nanomedicine and Biosensor Laboratory, School of Sciences, Harbin Institute of Technology, Harbin 150080, China
    • Nanomedicine and Biosensor Laboratory, School of Sciences, Harbin Institute of Technology, Harbin 150080, China
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  • Weiguo Qiu,

    1. Department of Aerospace and Mechanical Engineering, Biomedical Engineering IDP and Bio5 Institute, University of Arizona, Tucson, Arizona 85721, USA
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  • Jinhong Zhang,

    1. Department of Mining and Geological Engineering, University of Arizona, Tucson, Arizona 85721, USA
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  • Xiaoyi Wu

    Corresponding author
    1. Department of Aerospace and Mechanical Engineering, Biomedical Engineering IDP and Bio5 Institute, University of Arizona, Tucson, Arizona 85721, USA
    • Department of Aerospace and Mechanical Engineering, Biomedical Engineering IDP and Bio5 Institute, University of Arizona, Tucson, Arizona 85721, USA.
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Abstract

original image

Polymerizable cholesteryl-succinyl silane was synthesized and fabricated into stable nanofibrous lipid membranes using a combined sol-gel and electrospinning process. The resulting nanofibrous lipid membranes are capable of functionally immobilizing membrane proteins such as antibodies, thereby enabling targeted cell capture via the antigen-antibody interactions.

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