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E-Selectin-Targeted Porous Silicon Particle for Nanoparticle Delivery to the Bone Marrow

Authors

  • Aman P. Mann,

    1. Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner St., Houston, TX 77030, USA
    2. Department of Nanomedicine and Biomedical Engineering, The University of Texas Health Science Center at Houston, 1825 Pressler St., Houston, TX 77030, USA
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  • Takemi Tanaka,

    1. Department of Pharmaceutical Sciences, Thomas Jefferson University, 130 S 9th St., Philadelphia, PA 19107, USA
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  • Anoma Somasunderam,

    1. Department of Nanomedicine and Biomedical Engineering, The University of Texas Health Science Center at Houston, 1825 Pressler St., Houston, TX 77030, USA
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  • Xuewu Liu,

    1. Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner St., Houston, TX 77030, USA
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  • David G. Gorenstein,

    1. Department of Nanomedicine and Biomedical Engineering, The University of Texas Health Science Center at Houston, 1825 Pressler St., Houston, TX 77030, USA
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  • Mauro Ferrari

    Corresponding author
    1. Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner St., Houston, TX 77030, USA
    • Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner St., Houston, TX 77030, USA.
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Abstract

original image

A multifunctional drug delivery system is developed comprising biodegradable porous silicon microparticles that act as motherships to ferry different types of imaging and therapeutic nanoparticles loaded within their porous structure. An E-selectin thioaptamer ligand is used to actively target this delivery system to the bone marrow vasculature where the payload is released as the porous silicon underwent degradation under physiological conditions.

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