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Cellular Association and Cargo Release of Redox-Responsive Polymer Capsules Mediated by Exofacial Thiols

Authors

  • Yan Yan,

    1. Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia
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  • Yajun Wang,

    1. Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia
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  • Joan K. Heath,

    1. Ludwig Institute for Cancer Research - Parkville, Royal Melbourne Hospital, Victoria 3050, Australia
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  • Edouard C. Nice,

    1. Ludwig Institute for Cancer Research - Parkville, Royal Melbourne Hospital, Victoria 3050, Australia
    2. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
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  • Frank Caruso

    Corresponding author
    1. Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia
    • Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.
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Abstract

Redox-responsive polymer capsules stabilized by disulfide bonds and loaded with hydrophobic cargo are prepared by templating mesoporous silica particles via layer-by-layer assembly. The thiols and disulfide bonds in the capsules interact with the exofacial thiols on the cell membrane, which regulate cellular association and cargo release from the capsules.

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