Communication “Advanced Healthcare Materials”

Charge-Shifting Click Capsules with Dual-Responsive Cargo Release Mechanisms

  1. Kang Liang†,
  2. Georgina K. Such†,
  3. Zhiyuan Zhu,
  4. Yan Yan,
  5. Hannah Lomas,
  6. Frank Caruso*

Article first published online: 9 AUG 2011

DOI: 10.1002/adma.201101690

Issue

Advanced Materials

Advanced Materials

Volume 23, Issue 36, pages H273–H277, September 22, 2011

Additional Information

How to Cite

Liang, K., Such, G. K., Zhu, Z., Yan, Y., Lomas, H. and Caruso, F. (2011), Charge-Shifting Click Capsules with Dual-Responsive Cargo Release Mechanisms. Adv. Mater., 23: H273–H277. doi: 10.1002/adma.201101690

Author Information

  1. Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia

  1. †

    K.L. and G.K.S. contributed equally to this work.

*Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.

Publication History

  1. Issue published online: 21 SEP 2011
  2. Article first published online: 9 AUG 2011
  3. Manuscript Revised: 1 JUL 2011
  4. Manuscript Received: 6 MAY 2011

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Keywords:

  • drug delivery;
  • dual-responsive materials;
  • controlled release;
  • layer-by-layer assembly;
  • click chemistry
Thumbnail image of graphical abstract

The assembly of responsive layer-by-layer-assembled click polymer capsules that exhibit dual-responsive cargo release mechanisms for the controlled release of cargo is reported. The capsules show reversible size changes between pH 6 and 7.4. The synergistic effects of pH and redox-potential allow for rapid and efficient cargo release at simulated intracellular conditions.

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