Advanced Materials

Charge-Shifting Click Capsules with Dual-Responsive Cargo Release Mechanisms

Authors

  • Kang Liang,

    1. Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia
    Current affiliation:
    1. K.L. and G.K.S. contributed equally to this work.
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  • Georgina K. Such,

    1. Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia
    Current affiliation:
    1. K.L. and G.K.S. contributed equally to this work.
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  • Zhiyuan Zhu,

    1. Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia
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  • Yan Yan,

    1. Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia
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  • Hannah Lomas,

    1. Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia
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  • Frank Caruso

    Corresponding author
    1. Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia
    • Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.
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Abstract

The assembly of responsive layer-by-layer-assembled click polymer capsules that exhibit dual-responsive cargo release mechanisms for the controlled release of cargo is reported. The capsules show reversible size changes between pH 6 and 7.4. The synergistic effects of pH and redox-potential allow for rapid and efficient cargo release at simulated intracellular conditions.

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