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Advanced Materials

Cytophilic Fluorescent Bioprobes for Long-Term Cell Tracking

Authors

  • Yong Yu,

    1. Department of Chemical and Biomolecular Engineering, HKUST, Clear Water Bay, Kowloon, Hong Kong, China
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  • Chao Feng,

    1. Department of Chemical and Biomolecular Engineering, HKUST, Clear Water Bay, Kowloon, Hong Kong, China
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  • Yuning Hong,

    1. Department of Chemistry, Institute of Molecular Functional Materials, The Hong Kong University of Science and Technology (HKUST), Kowloon, Hong Kong, China
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  • Jianzhao Liu,

    1. Department of Chemistry, Institute of Molecular Functional Materials, The Hong Kong University of Science and Technology (HKUST), Kowloon, Hong Kong, China
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  • Sijie Chen,

    1. Department of Chemistry, Institute of Molecular Functional Materials, The Hong Kong University of Science and Technology (HKUST), Kowloon, Hong Kong, China
    2. Bioengineering Graduate Program, HKUST, Clear Water Bay, Kowloon, Hong Kong, China
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  • Ka Ming Ng,

    1. Department of Chemical and Biomolecular Engineering, HKUST, Clear Water Bay, Kowloon, Hong Kong, China
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  • Kathy Qian Luo,

    Corresponding author
    1. Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore
    • Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore
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  • Ben Zhong Tang

    Corresponding author
    1. Department of Chemistry, Institute of Molecular Functional Materials, The Hong Kong University of Science and Technology (HKUST), Kowloon, Hong Kong, China
    2. Bioengineering Graduate Program, HKUST, Clear Water Bay, Kowloon, Hong Kong, China
    • Department of Chemistry, Institute of Molecular Functional Materials, The Hong Kong University of Science and Technology (HKUST), Kowloon, Hong Kong, China.
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Abstract

Molecules of silolesare almost non-fluorescent but their nanoaggregates are highly emissive, exhibiting aggregation-induced emission (AIE). The AIE-active aggregates are cytocompatible with living cells, stain cytoplasms of HeLa cells indelibly without contaminating another type of cell line in a co-culture system, and remain visible for a long period of time.

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