Controlled Protein Delivery Based on Enzyme-Responsive Nanocapsules

Authors

  • Jing Wen,

    1. Key Laboratory for Green Chemical Technology of State Education Ministry, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China
    2. Department of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA 90095, USA
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  • Sean M. Anderson,

    1. Department of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA 90095, USA
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  • Juanjuan Du,

    1. Department of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA 90095, USA
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  • Ming Yan,

    1. Department of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA 90095, USA
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  • Jun Wang,

    1. Key Laboratory for Green Chemical Technology of State Education Ministry, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China
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  • Meiqing Shen,

    Corresponding author
    1. Key Laboratory for Green Chemical Technology of State Education Ministry, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China
    • Meiqing Shen, Key Laboratory for Green Chemical Technology of State Education Ministry, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China

      Yunfeng Lu, Department of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA 90095, USA.

      Tatiana Segura, Department of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA 90095, USA.

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  • Yunfeng Lu,

    Corresponding author
    1. Department of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA 90095, USA
    • Meiqing Shen, Key Laboratory for Green Chemical Technology of State Education Ministry, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China

      Yunfeng Lu, Department of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA 90095, USA.

      Tatiana Segura, Department of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA 90095, USA.

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  • Tatiana Segura

    Corresponding author
    1. Department of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA 90095, USA
    • Meiqing Shen, Key Laboratory for Green Chemical Technology of State Education Ministry, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China

      Yunfeng Lu, Department of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA 90095, USA.

      Tatiana Segura, Department of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA 90095, USA.

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Abstract

original image

Enzyme-responsive protein nanocapsules are synthesized to release their protein cargoes in response to specific enzymes secreted in certain cellular events with both specificity and with a controlled rate by composition tuning. The unique nanocapsule structures protect the encapsulated proteins during hydrogel synthesis, providing a new direction for responsive protein delivery according to specific cellular events or the local environment.

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