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Design of a Cellular-Uptake-Shielding “Plug and Play” Template for Photo Controllable Drug Release

Authors

  • Wang Xiao,

    1. Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, China
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  • Wei-Hai Chen,

    1. Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, China
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  • Xiao-Ding Xu,

    1. Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, China
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  • Cao Li,

    1. Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, China
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  • Jing Zhang,

    1. Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, China
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  • Ren-Xi Zhuo,

    1. Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, China
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  • Xian-Zheng Zhang

    Corresponding author
    1. Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, China
    • Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, China.
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Abstract

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A novel template was designed for photocontrollable drug release. Multiple functional groups can be loaded and unloaded onto the template via UV irradiation. Importantly, the template can inhibit loaded drug being uptaken by normal cells. However, upon the irradiation of UV light to the target site, such as tumor tissues, the loaded drug can be released from the template quickly and thereafter endocytosed by target cells to achieve the desirable cure effect.

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