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Enhanced Magnetic Resonance Contrast of Fe3O4 Nanoparticles Trapped in a Porous Silicon Nanoparticle Host

Authors

  • Joseph M. Kinsella,

    1. Department of Chemistry & Biochemistry, University of California, San Diego, 92093, La Jolla, CA, USA
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  • Shalini Ananda,

    1. Materials Science and Engineering, University of California, San Diego, 92093, La Jolla, CA, USA
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  • Jennifer S. Andrew,

    1. Department of Chemistry & Biochemistry, University of California, San Diego, 92093, La Jolla, CA, USA
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  • Joel F. Grondek,

    1. Department of Chemistry & Biochemistry, University of California, San Diego, 92093, La Jolla, CA, USA
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  • Miao-Ping Chien,

    1. Department of Chemistry & Biochemistry, University of California, San Diego, 92093, La Jolla, CA, USA
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  • Miriam Scadeng,

    1. Department of Radiology, University of California, San Diego, 92093, La Jolla, CA, USA
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  • Nathan C. Gianneschi,

    1. Department of Chemistry & Biochemistry, University of California, San Diego, 92093, La Jolla, CA, USA
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  • Erkki Ruoslahti,

    1. Center for Nanomedicine, Sanford Burnham Medical Research Institute at the University of California, Santa Barbara, 93106, Santa Barbara, CA, USA
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  • Michael J. Sailor

    Corresponding author
    1. Department of Chemistry & Biochemistry, University of California, San Diego, 92093, La Jolla, CA, USA
    2. Materials Science and Engineering, University of California, San Diego, 92093, La Jolla, CA, USA
    3. Department of Bioengineering, University of California, San Diego, 92093, La Jolla, CA, USA
    • Department of Chemistry & Biochemistry, University of California, San Diego, 92093, La Jolla, CA, USA.
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Abstract

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A composite material consisting of Fe3O4 nanoparticles embedded in a 200 nm-diameter porous Si (pSi) nanoparticle “superstructure” is prepared as a potential magnetic resonance imaging contrast agent. Dipolar magnetic coupling between Fe3O4 nanoparticles is enhanced due to their proximity in the pSi host matrix, resulting in an increase in the saturation magnetization and coercivity of the composite.

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