The choline transporter (ChT) is used to transporte choline-derivate-modified nanoparticles across the blood-brain barrier. It is demonstrated that ChT is an ideal Trojan horse. The choline-derivate-modified nanoparticles exhibit higher permeability across the brain capillary endothelial cells (BCECs) monolayer in vitro and higher gene distribution and expression in vivo.
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