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Choline-Derivate-Modified Nanoparticles for Brain-Targeting Gene Delivery

Authors

  • Jianfeng Li,

    1. Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China
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  • Lu Zhou,

    1. Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA Department of Medical Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China
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  • Deyong Ye,

    1. Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA Department of Medical Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China
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  • Shixian Huang,

    1. Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China
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  • Kun Shao,

    1. Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China
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  • Rongqin Huang,

    1. Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China
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  • Liang Han,

    1. Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China
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  • Yang Liu,

    1. Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China
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  • Shuhuan Liu,

    1. Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China
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  • Liya Ye,

    1. Institute of Clinical Medical Sciences, China–Japan Friendship Hospital, The Ministry of Health, Beijing, China
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  • Jinning Lou,

    1. Institute of Clinical Medical Sciences, China–Japan Friendship Hospital, The Ministry of Health, Beijing, China
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  • Chen Jiang

    Corresponding author
    1. Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China
    • Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
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Abstract

The choline transporter (ChT) is used to transporte choline-derivate-modified nanoparticles across the blood-brain barrier. It is demonstrated that ChT is an ideal Trojan horse. The choline-derivate-modified nanoparticles exhibit higher permeability across the brain capillary endothelial cells (BCECs) monolayer in vitro and higher gene distribution and expression in vivo.

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