Advanced Materials

A Graphene–Conjugated Oligomer Hybrid Probe for Light-Up Sensing of Lectin and Escherichia Coli

Authors

  • Lihua Wang,

    1. Department of Chemical and Biomolecular Engineering, 4 Engineering Drive 4, National University of Singapore, 117576, Singapore
    2. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
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  • Kan-Yi Pu,

    1. Department of Chemical and Biomolecular Engineering, 4 Engineering Drive 4, National University of Singapore, 117576, Singapore
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  • Jing Li,

    1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
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  • Xiaoying Qi,

    1. School of Materials Science and Engineering, Nanyang Technological University, Nanyang 639798, Singapore
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  • Hai Li,

    1. School of Materials Science and Engineering, Nanyang Technological University, Nanyang 639798, Singapore
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  • Hua Zhang,

    1. School of Materials Science and Engineering, Nanyang Technological University, Nanyang 639798, Singapore
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  • Chunhai Fan,

    Corresponding author
    1. Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
    • Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
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  • Bin Liu

    Corresponding author
    1. Department of Chemical and Biomolecular Engineering, 4 Engineering Drive 4, National University of Singapore, 117576, Singapore
    • Department of Chemical and Biomolecular Engineering, 4 Engineering Drive 4, National University of Singapore, 117576, Singapore.
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Abstract

A water-soluble neutral fluorescent conjugated oligomer (FBT) is integrated with graphene oxide (GO) to form a hybrid nanoprobe with extremely low fluorescence background due to the robust quenching capability of GO. The contact between GO and FBT can be effectively shielded by Concanavalin A because of the strong specific protein–carbohydrate interaction, which ultimately allows for light-up visual detection of lectin and Escherichia coli.

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