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Keywords:

  • nanodiamonds;
  • nanomedicine;
  • drug delivery;
  • DNA;
  • Paclitaxel
Thumbnail image of graphical abstract

Multimodal nanodiamonds (NDs) were prepared by attaching fluorescently labeled drug-oligonucleotide conjugates and monoclonal antibodies onto the ND surface. Fluorescently labeled oligonucleotide linkers enabled the intracellular observation and quantification of resultant ND conjugates. The covalent attachment of the chemotherapeutic and targeting moiety to the ND surface significantly enhanced cellular internalization and therapeutic activity