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Advanced Materials

Multimodal Nanodiamond Drug Delivery Carriers for Selective Targeting, Imaging, and Enhanced Chemotherapeutic Efficacy

Authors

  • Xue-Qing Zhang,

    1. Department of Biomedical Engineering, Northwestern University Evanston, Illinois 60208, USA
    Current affiliation:
    1. X.-Q.Z. and R.L. contributed equally to this work.
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  • Robert Lam,

    1. Department of Mechanical Engineering, Northwestern University Evanston, Illinois 60208, USA
    Current affiliation:
    1. X.-Q.Z. and R.L. contributed equally to this work.
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  • Xiaoyang Xu,

    1. Department of Chemistry, Northwestern University Evanston, Illinois 60208, USA
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  • Edward K. Chow,

    1. George Williams Hooper Foundation, University of California, San Francisco, San Francisco, CA 94143, USA
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  • Ho-Joong Kim,

    1. Department of Biomedical Engineering, Northwestern University Evanston, Illinois 60208, USA
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  • Dean Ho

    Corresponding author
    1. Department of Biomedical Engineering, Northwestern University Evanston, Illinois 60208, USA
    2. Department of Mechanical Engineering, Northwestern University Evanston, Illinois 60208, USA
    3. Institute for Bionanotechnology in Medicine (IBNAM), Northwestern University Chicago, IL, 60611, USA
    4. Robert H. Lurie Comprehensive Cancer Center, Chicago, IL 60611, USA
    • Department of Biomedical Engineering, Northwestern University Evanston, Illinois 60208, USA.
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Abstract

Multimodal nanodiamonds (NDs) were prepared by attaching fluorescently labeled drug-oligonucleotide conjugates and monoclonal antibodies onto the ND surface. Fluorescently labeled oligonucleotide linkers enabled the intracellular observation and quantification of resultant ND conjugates. The covalent attachment of the chemotherapeutic and targeting moiety to the ND surface significantly enhanced cellular internalization and therapeutic activity

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