Get access
Advanced Materials

Efficient Delivery of Gold Nanoparticles by Dual Receptor Targeting

Authors

  • Sanjib Bhattacharyya,

    1. Department of Biochemistry and Molecular Biology, Guggenheim 1311B College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Search for more papers by this author
  • Jameel Ahmad Khan,

    1. Department of Biochemistry and Molecular Biology, Guggenheim 1311B College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Search for more papers by this author
  • Geoffry L. Curran,

    1. Neuroscience Research, Guggenheim 1311B College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Search for more papers by this author
  • J. David Robertson,

    1. Department of Chemistry and University of Missouri Research Reactor, University of Missouri, 601 S. College Avenue, MO- 65211, USA
    Search for more papers by this author
  • Resham Bhattacharya,

    1. Department of Biochemistry and Molecular Biology, Guggenheim 1311B College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Search for more papers by this author
  • Priyabrata Mukherjee

    Corresponding author
    1. Department of Biochemistry and Molecular Biology, Guggenheim 1311B College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    2. Biomedical Engineering, Guggenheim 1311B College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    3. Cancer Center, College of Medicine, Guggenheim 1311B College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    • Department of Biochemistry and Molecular Biology, Guggenheim 1311B College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
    Search for more papers by this author

Abstract

The fabrication and characterization of a dual receptor targeted system (DRTS) are described. It is demonstrated that DRTS is more efficient at delivering gold nanoparticles (AuNPs) to ovarian cancer cells expressing epidermal growth factor receptor (EGFR) and folate receptor (FR) than their corresponding single-receptor-targeting systems (SRTS).

original image
Get access to the full text of this article

Ancillary