Nanogel Star Polymer Architectures: A Nanoparticle Platform for Modular Programmable Macromolecular Self-Assembly, Intercellular Transport, and Dual-Mode Cargo Delivery



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Nanogel star polymers are developed as a new route for the formation of dual-mode nanoparticle systems for applications in the areas of synergistic therapeutic delivery, imaged therapeutic delivery, and dual-mode bioimaging agents. These extremely uniform, structurally versatile, water-soluble, unimolecular organic nanoparticles with tunable polyvalency and functionality are preprogrammed to spontaneously upload different types of complex functional macromolecules.