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Aptamer-Mediated Efficient Capture and Release of T Lymphocytes on Nanostructured Surfaces

Authors

  • Li Chen,

    1. Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China
    2. Graduate School of Chinese Academy of Sciences, Beijing, 100864, P. R. China
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  • Xueli Liu,

    1. Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China
    2. Graduate School of Chinese Academy of Sciences, Beijing, 100864, P. R. China
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  • Bin Su,

    1. Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China
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  • Jing Li,

    1. National Centre for NanoScience and Technology, Beijing, 100190, P. R. China
    2. Graduate School of Chinese Academy of Sciences, Beijing, 100864, P. R. China
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  • Lei Jiang,

    1. Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China
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  • Dong Han,

    Corresponding author
    1. National Centre for NanoScience and Technology, Beijing, 100190, P. R. China
    • National Centre for NanoScience and Technology, Beijing, 100190, P. R. China
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  • Shutao Wang

    Corresponding author
    1. Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China
    • Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
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Abstract

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A nanostructured platform that combines silicon nanowire arrays and DNA aptamers realizes significant capture and efficient release of T lymphocytes. An approximately two orders of magnitude enhancement in capture efficiency compared to planar surfaces is observed with good release performance. This method of capture and release provides an artful strategy to fulfill the demands of cell isolation and diagnosis.

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